To survey the current
state of knowledge about the biology of psychopathology. Primary realms
of psychopathology to be covered include depression, anxiety, psychopathology,
addiction, and schizophrenia. Both central and peripheral mechanisms will
be considered in our attempts to convey what is known about the key biological
systems involved int he various forms of psychopathology. Key conceptual
issues relating to emotion, diagnosis, and psychopathology will be major
themes throughout the course. Biological perspectives on developmental
psychopathology and treatment will also be addressed
The seminars are designed to be interactive. Two readings
are required each week. Because there are so many additional readings
that are excellent and highly relevant, they have been included below
the two required readings, which are asterisked. We have listed the additional
readings in order of importance and relevance.
Instructors:
Heather C. Abercrombie
Phone: 3-6126
Email: hcabercr@wisc.edu
Jack B. Nitschke
Phone: 3-6083
Email: jnitschke@wisc.edu
September
21, Class 1: Biological perspectives on the psychopathology:
Introduction and overview
*Miller,
G. A., & Keller, J. (2000). Psychology and neuroscience: Making peace.
Current Directions in Psychological Science, 9, 212-215.
*Kosslyn,
S. M., Cacioppo, J. T., & Davidson, R. J., Hugdahl, K., Lovallo,
W.R., Spiegel, D., & Rose, R. (2002). Bridging psychology and biology:
The analysis of individuals in groups. American Psychologist, 57, 341-351.
Davidson,
R. J. (1997). The proper role of psychology in psychopathology research:
Four noble truths. Psychopathology Research, 8, 1-9.
Miller, G. A. (1996). How we think about cognition, emotion,
and biology in psychopathology. Psychophysiology, 33, 615-628.
Hyman, S.E. (2003). Diagnosing
disorders. Scientific American, 289, 96-103.
Gage, F. H. (2003). Brain,
repair yourself. Scientific American, 289, 46-53.
Holloway, M. (2003). The
mutable brain. Scientific American, 289, 78-85.
September 28, Class
2: Key biological systems in emotion: Functional neuroanatomy
and LHPA axis
Functional neuroanatomy
*Dalgleish,
T. (2004) The emotional brain. Nature Reviews Neuroscience, 5, 582-589.
Davidson,
R. J., Jackson, D.C., & Kalin, N. H. (2000). Emotion, plasticity, context,
and regulation: Perspectives from affective neuroscience. Psychological
Bulletin, 126, 890-909.
Davis, M., & Whalen, P.
J. (2001). The amygdala: Vigilance and emotion. Molecular Psychiatry,
6, 13-34.
Rolls,
E.T. (2004) The functions of the orbitofrontal cortex. Brain & Cognition,
55, 11-29.
Gusnard,
D. A. & Raichle, M. E. (2001). Searching for a baseline: Functional
imaging and the resting human brain. Nature Reviews Neuroscience, 2(10),
685-94.
Davidson,
R. J. (2000). Affective style, psychopathology, and resilience: Brain
mechanisms and plasticity. American Psychologist, 55, 1196-1214.
Davidson, R. J., & Irwin,
W. (1999). The functional neuroanatomy of emotion and affective style.
Trends in Cognitive Science, 3, 11-21.
Hariri, A. R., Mattay, V.
S., Tessitore, A.D., Kolachana, B., Fera, F., Goldman, D., Egan, M. F.,
& Weinberger, D. R. (2002). Serotonin transporter genetic variation and
the response of the human amygdala. Science, 297, 400-403.
Damasio, A. R. (1994). Descartes' error: Emotion, reason,
and the human brain. New York: Avon.
LeDoux, J. E. (1996). The emotional brain. New York:
Simon and Schuster.
LeDoux, J. E. (2002). Synaptic self: How our brains become who we are.
New York: Viking.
Rolls, E. T. (1999). The brain and emotion. New York: Oxford
University Press.
LHPA
*Raison,
C. L. & Miller, A. H. (2003). When not enough is too much: The role
of insufficient glucocorticoid signaling in the pathophysiology of stress-related
disorders. American Journal of Psychiatry, 160, 1554-65.
Levine,
S. (2000). Influence of psychological variables on the activity of the
hypothalamic-pituitary-adrenal axis. European Journal of Pharmacology,
405, 149-160.
Dickerson,
S. S., & Kemeny, M. E. (2004). Acute stressors and cortisol responses:
A theoretical integration and synthesis of laboratory research.
Psychological Bulletin, 130, 355-391.
Gould,
E., & Tanapat, P. (1999). Stress and hippocampal neurogenesis. Biological
Psychiatry, 46, 1472-1479.
Sapolsky,
R. M., Krey, L. C., & McEwen, B. S. (1986). The neuroendocrinology of
stress and aging: The glucocorticoid cascade hypothesis. Endocrine
Reviews, 7, 284-301.
Sapolsky,
R.M., Meaney, M. J., & McEwen, B. S. (1985). The development of the
glucocorticoid receptor system in the rat limbic brain: III. Negative
feedback regulation. Brain Research, 350, 169-173.
Sapolsky,
R. M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric
disorders. Archives of General Psychiatry, 57, 925-935.
McEwen,
B. S. (1998). Protective and damaging effects of stress mediators. New
England Journal of Medicine, 338, 171-179.
McEwen,
B. S. (2000). Effects of adverse experience for brain structure and function.
Biological Psychiatry, 48, 721-731.
October 5,
Class 3: Emotion regulation and dysregulation
*Myers, K. M., & Davis, M. (2002).
Behavioral and neural analysis of extinction. Neuron, 36, 567-584.
*Ochsner, K., Bunge,
S. A., Gross, J. J., & Gabrieli, J. D. (2002). Rethinking feelings: An
FMRI study of the cognitive regulation of emotion. Journal of Cognitive
Neuroscience, 14, 1215-1229.
Gross, J. J. (2002). Emotion
regulation: Affective, cognitive, and social consequences. Psychophysiology,
39, 281-291.
Jackson, D.C., Malmstadt,
J. R., Larson, C. L., & Davidson, R. J. (2000). Suppression and enhancement
of emotional responses to unpleasant pictures. Psychophysiology,
37, 515-522.
Schaefer, S. M., Jackson,
D.C., Davidson, R.J Aguirre, G. K., Kimberg, D. Y., & Thompson-Schill,
S. L. (2002). Modulation of amygdalar activity by the conscious regulation
of negative emotion. Journal of Cognitive Neuroscience, 14, 913-921.
Milad, M. R., & Quirk, G. J. (2002).
Neurons in medial prefrontal cortex signal memory for fear extinction.
Nature, 420, 70-74.
Brown, L. L., Tomarken,
A. J., Orth, D. N., Loosen, P. T., Kalin, N. H., & Davidson, R. J. (1996).
Individual differences in repressive-defensiveness predict basal salivary
cortisol levels. Journal of Personality of Social Psychology,
70, 362-371.
October
12, Class 4: Basic and clinical neuroscience of fear and anxiety
*Davis, M. (1998). Are different parts of the extended amygdala
involved in fear versus anxiety? Biological Psychiatry, 44, 1239-1247.
*Nitschke, J. B., & Heller, W. (2002). The neuropsychology
of anxiety disorders: Affect, cognition, and neural circuitry. In H. D'Haenen,
J. A. den Boer, & P. Willner (Eds.), Biological Psychiatry (pp.
975-988). Chichester, UK: John Wiley & Sons, Ltd.
Bakshi,
V. P., & Kalin, N. H. (2000). Corticotropin-releasing hormone and
animal models of anxiety: Gene-environment interactions. Biological
Psychiatry, 48, 1175-1198.
Charney, D.
S., Grillon, C. G., & Bremner, J. D. (1998). The neurobiological basis
of anxiety and fear: Circuits, mechanisms, and neurochemical interactions
(Part 1). Neuroscientist, 4, 35-44.
Charney, D. S., Grillon, C. G., & Bremner, J. D. (1998) The
neurobiological basis of anxiety and fear: Circuits, mechanisms, and neurochemical
interactions (Part 2). Neuroscientist, 4, 122-132.
Rauch, S. L., Savage, C. R., Alpert, N. M., Fischman, A. J.,
& Jenike, M. A. (1997). The functional neuroanatomy of anxiety: A study
of three disorders using positron emission tomography and symptom provocation.
Biological Psychiatry, 42, 446-452.
LeDoux, J. E. (1996). The emotional brain. New York:
Simon and Schuster.
LeDoux, J. E. (2002). Synaptic self: How our brains become who we are.
New York: Viking.
LeDoux, J. (1998). Fear
and the brain: Where have we been, and where are we going? Biological
Psychiatry, 44, 1229-1238.
Kalin, N. H., Shelton, S.E., Rickman, M., & Davidson, R. J.
(1998). Individual differences in freezing and cortisol in infant and
rhesus monkeys. Behavioral Neuroscience, 112, 286-292.
Kalin, N. H., Shelton, S.E., & Davidson, R. J. (2000). Cerebrospinal
fluid corticotropin-releasing hormone levels are elevated in monkeys with
patterns of brain activity associated with fearful temperament. Biological
Psychiatry, 47, 579-585.
Kalin, N. H., Shelton,
S.E., davidson, R. J., & Kelley, A. E. (2001). The primate amygdala mediates
acute fear but not behavioral and physiological components of anxious
temperament. Journal of Neuroscience, 21, 2067-2074.
Grillon, C.G.
(2002). Startle reactivity and anxiety disorders: Aversive conditioning,
context, and neurobiology. Biological Psychiatry, 52, 958-975.
October 19,
Class 5: Functional neuroanatomy of depression
*Davidson, R. J.,
Pizzagalli, D., Nitschke, J. B., & Putnam, K. (2002). Depression: Perspectives
from affective neuroscience. Annual Review of Psychology, 53,
545-574.
Seminowicz,
D.A., Mayberg, H.S. et al. (2004). Limbic-frontal circuitry in major
depression: A path modeling meta-analysis, Neuroimage, 22, 409-418.
Sheline,
Y. I. (2003). Neuroimaging studies of mood disorder effects on the brain.
Biological Psychiatry, 54, 338-352.
Drevets, W. C. (2003). Neuroimaging abnormalities in the amygdala
in mood disorders. Annals of the New York Academy of Sciences,
98, 420-444.
Drevets, W. C. (2001).
Neuroimaging and neuropathological studies of depression: Implications
for the cognitive-emotional features of mood disorders. Current Opinion
in Neurobiology, 11, 240-249.
Jacobs, B. L. (2004).
Depression. The brain finally gets into the act. Current Directions
in Psychological Science, 13, 103-106.
Sapolsky,
R. M. (2004). Is impaired neurogenesis relevant to the affective symptoms
of depression? Biological Psychiatry, 56, 137-139.
Duman,
R. S. (2004) Depression: A case of neuronal life and death? Biological
Psychiatry, 56, 140-145.
Henn,
F. A. & Vollmayr, B. (2004) Neurogenesis and depression: Etiology
or epiphenomenon? Biological Psychiatry, 56, 146-150.
Mayberg, H.
S. (2003). Modulating dysfunctional limbic-cortical circuits in depression:
Towards development of brain-based algorithms for diagnosis and optimized
treatment. British Medical Bulletin, 65, 193-207.
Heller, W., & Nitschke, J. B. (1997). Regional brain activity in emotion:
A framework for understanding cognition in depression. Cognition and Emotion,
11, 637-661.
Heller, W., & Nitschke, J. B. (1998).
The puzzle of the regional brain activity in depression and anxiety:
The importance of subtypes and comorbidity. Cognition and Emotion,
12, 421-447.
MacQueen, G. M., Campbell,
S., McEwen, B. S., MacDonald. K., Amano, S., Joffe, R. T., Nahmias, C.,
& young, L. T. (2003). Course of illness, hippocampal function, and hippocampal
volume in major depression. Proceedings of the National Academy of
Sciences, 1000, 1387-1392.
Davidson, R. J.,
Abercombie, H., Nitschke, J. B., & Putnam, K. (1999). Regional brain function,
emotion and disorders of emotion. Current Opinion in Neurobiology,
9, 228-234.
Rajkowska, G. (2000).
Postmortem studies in mood disorders indicate altered numbers on neurons
and glial cells. Biological Psychiatry, 48, 766-777.
Caspi, A., Sugden, K., Moffitt,
T. E., Taylor, A., Crag, I. W., Harrington, H., McClay, J., Mill, J.,
Martin, J., Braithwaite, A., & Poulton, R. (2003). Influence of life stress
on depression: Moderation by a polymorphism in the 5-HTT gene, Science,
301, 386-389.
October 26,
Class 6: LHPA axis in depression and PTSD
*Raison,
C. L. & Miller, A. H. (2003). When not enough is too much: The role
of insufficient glucocorticoid signaling in the pathophysiology of stress-related
disorders. American Journal of Psychiatry, 160, 1554-65.
Gold,
P. W., Drevets, W. C., & Charney, D. S. (2002). New insights into
the role of cortisol and the glucocorticoid receptor in severe depression.
Biological Psychiatry, 52, 381-385.
Pariante,
C. M. (2003). Depression, stress and the adrenal axis. Journal of Neuroendocrinology,
15, 811-812
*Sapolsky,
R. M. (2003). Taming stress. Scientific American, 289, 86-95.
Belanoff,
J. K., Rothschild, A. J., Cassidy, F., DeBattista, C., Baulieu E.-E.,
Schold, C., & Schatzberg A. F. (2002). An open label trial of C-1073
(mifepristone) for psychotic major depression. Biological Psychiatry,
52, 386-392.
Young,
E. A., Lopez, J. F., Murphy-Weinberg, V., Watson, S. J., & Akil,
H. (2003). Mineralocorticoid receptor function in major depression.
Archives of General Psychiatry, 60, 24-28.
Young, E. A., Haskett, R. F.,
Murphy-Weinberg, V., Watson, S. J., & Akil, H. (1991). Loss of glucocorticoid
fast feedback in depression. Archives of General Psychiatry,
48, 693-699.
Pariante, C. M., & Miller,
A. H. (2002). Glucocorticoid receptors in major depression: Relevance
to pathophysiology and treatment. Biological Psychiatry, 49,
391-404.
Pariante, C. M., & Miller, A. H. (2002). Glucocorticoid receptors
in major depression: Relevance to pathophysiology and treatment. Biological
Psychiatry, 49, 391-404.
Gilbertson, M. W.,
Shenton, N.E., Cizewski, A., Kasai, K., Lasko, N.B., Orr, S. P., & Pitman,
R. K. (2002). Smaller hippocampal volume predicts pathologic vulnerability
to psychological trauma. Nature Neuroscience, 5, 1242-1247.
Sapolsky, R.M. (2002).
Chickens, eggs, and hippocampal atrophy. Nature Neuroscience,
5, 1111-1113.
Meaney, M. J. (2001). Maternal care, gene expression,
and the transmission of individual differences in stress reactivity across
generations. Annual Review of Neuroscience, 24, 1161-1192.
Sapolsky, R.M. (2003).
Taming stress. Scientific American, 289, 86-95.
Sapolsky, R.M. (2000). The possibility of neurotoxicity in
the hippocampus in major depression: A primer on neuron death. Biological
Psychiatry, 48, 755-765.
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002).
Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol
levels.Pharmacology, Biochemistry & Behavior, 71, 431-447.
Reul, J., & Holsboer, F. (2002). Corticotropin-releasing factor
receptors 1 and 2 anxiety and depression. Current Opinion in Pharmacology,
2, 23-33.
November
2, Class 7: Biological perspectives on addiction and substance-related disorders (Anne Kelley:
guest lecturer)
Kelley, A.E., & Berridge, K.C.
(2002). The neuroscience of natural rewards: Relevance to addictive
drugs. Journal of Neuroscience, 22, 3306-3311.
Koob, G. F., Ahmed,
S. H., Boutrel, B., Chen S. A., Kenny, P. J., Markou, A., O'Dell, L.
E., Parsons, L. H., & Sanna, P. P. (2003). Neurobiological mechanisms
in the transition from drug use to drug dependence. Neuroscience &
Biobehavioral Reviews, 27, 739-749.
Koob,
G. F. & Le Moal, M. (2001). Drug addiction, dysregulation of reward,
and allostasis. Neuropsychopharmacology, 24, 97-129.
Goldstein
RZ. & Volkow ND. (2002). Drug addiction and its underlying neurobiological
basis: neuroimaging evidence for the involvement of the frontal cortex.
American Journal of Psychiatry, 159, 1642-52.
November
9, Class 8: Biological perspectives on food intake and eating disorders (Anne Kelley:
guest lecturer)
Klein
DA. & Walsh BT. (2004). Eating disorders: clinical features and pathophysiology.
Physiology & Behavior, 81, 359-74.
Kelley
AE. (2004). Ventral striatal control of appetitive motivation: role
in ingestive behavior and reward-related learning. Neuroscience & Biobehavioral
Reviews, 27, 765-76.
Hanlon
EC. Baldo BA. Sadeghian K. & Kelley AE. (2004). Increases in food intake
or food-seeking behavior induced by GABAergic, opioid, or dopaminergic
stimulation of the nucleus accumbens: is it hunger?. Psychopharmacology,
172, 241-7.
November
16, Class 9: Biological perspectives on psychopathy (Joe
Newman: guest lecturer)
Newman, J. P.,
Hiatt, K. D., & MacCoon, D. G. (in press). Cognitive and affective
neuroscience in disinhibitory psychopathology: Summary and integration.
In D. Barch (Ed.) Cognitive and Affective Neuroscience of Psychopathology,
Oxford University Press.
Blair, R. J. R. (in press). Understanding
the development of the psychopathic individual: An affective cognitive
neuroscience approach. In D. Barch (Ed.) Cognitive and Affective
Neuroscience of Psychopathology,, Oxford University Press.
Ishikawa, S. S., & Raine, A. (in press). Contributions of
prefrontal lobe subregions to antisocial and aggressive behavior. In D. Barch (Ed.)
Cognitive and Affective Neuroscience of Psychopathology, Oxford University Press.
November
23, Class 10: Biological
perspectives on schizophrenia (Giulio Tononi: guest Lecturer)
*Callicot, J. H. (2003). An
expanded role for functional neuroimaging in schizophrenia. Current
Opinion in Neurobiology, 13, 256-260.
*Sawa, A., & Snyder, S. H.
(2002). Schizophrenia: Diverse approaches to a complex disease. Science,
26, 692-695.
Thaker, G. K., & Carpenter, W. T.
(2001). Advances in schizophrenia. Nature Medicine, 7, 667-671.
Kuperberg, G., & Heckers, S.
(2000). Schizophrenia and cognitive function. Current Opinion in Neurobiology,
10, 205-210.
November
30, Class 11: Biological
perspectives on developmental psychopathology
*Krause, K., Dresel, S.
H., Krause, J., la Fougere, C., & Ackenheil, M. (2003). The dopamine transporter
and neuroimaging in attention deficit hyperactivity disorder. Neuroscience
and Behavioral Reviews, 27, 605-613. *Coe, C. L., Kramer,
M., Czeh, B., Gould, E., Reeves, A. J., Kirschbaum, C. et al. (2003).
Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile
rhesus monkeys. Biological Psychiatry, 54, 1025-1034.
Zahn-Waxler, C., Klimes-Doughan,
B., & Slattery, M. J. (2000). Internalizing problems of childhood and
adolescence: Prospects, pitfalls, and progress in understanding the development
of anxiety and depression. Development and Psychopathology, 12,
443-466.
Buss, K. A., Malmstadt
Schumacher, J. R., Dolski, I., Kalin, N. H., Goldsmith, H. H., & Davidson,
R. J. (2003). Right frontal brain activity, cortisol, and withdrawal behavior
in 6-month-old infants. Behavioral Neuroscience, 117, 11-20.
Schwartz, C. E., Wright,
C. I., Shin, L. M., Kagan, J., & Rauch, S. L. (2003). Inhibited and uninhibited
infants "grown up": Adult amygdalar response to novelty. Science,
300, 1952-1953.
Wilens, T. E., Biederman,
J., & Spencer, T. J. (2002). Attention deficit/hyperactivity disorder
across the lifespan. Annual Review of Medicine, 53, 113-131.
Mostofsky, S. H., Cooper,
K. L., Kates, W. R., Denckla, M. B., & Kaufman, W. E. (2002). Smaller
prefrontal and premotor volumes in boys with attention-deficit/hyperactivity
disorder. Biological Psychiatry, 52, 785-794.
Thomas, K. M., Drevets,
W. C., Dahl, R. E., Ryan, N. D., Birmaher, B., Eccard, C. H., Axelson, D.,
Whalen, P. J., & Casey, B. J. (2001). Amygdala response to fearful faces in
anxious and depressed children. Archives of General Psychiatry, 58, 1057-1063.
McClure, E. B.,
Pope, K., Hoberman, A. J., Pine, D. S., & Leibenluft, E. (2003). Facial
expression recognition in adolescents with mood and anxiety disorders.
American Journal of Psychiatry, 160, 1172-1174.
Pollak,
S. D., & Kistler, D. J. (2002). Early experience is associated with the
development of categorical representations for facial expressions of emotion.
Proceedings of the National Academy of Sciences, 99, 9072-9076.
Pollak, S. D., & Sinha, P.
(2002). Effects of early experience in children's recognition of facial
displays of emotion. Developmental Psychology, 38, 784-791.
December
7, Class 12: Biology and the treatment of psychopathology
*Kandel, E. R. (1998). A new
intellectual framework for psychiatry. American Journal of Psychiatry, 155, 457-469.
*Pariante,
C. M., Thomas, S. A., Lovestone, S., Makoff, A., & Kerwin, R. W.
(2004). Do antidepressants regulate how cortisol affects the brain?
Psychoneuroendocrinology, 29, 423-447.
Vermetten, E.,
Vythilingam, M., Southwick, S. M., Charney, D. S., & Bremner, J. D.
(2003). Long-term treatment with paroxetine increases verbal declarative
memory and hippocampal volume in posttraumatic stress disorder. Biological
Psychiatry, 54, 693-702.
Young, E. A., Altemus, M., Lopez,
J. F., Kocsis, J. H., Schatzberg, A. F., deBattista, C., & Zubieta,
J.-K. (2004). HPA axis activation in major depression and response to
fluoxetine: A pilot study. Psychoneuroendocrinology, 29, 1198-1204.
Goldapple,
K., Segal, Z., Garson, C., Lau, M., Bieling, P., Kennedy, S., &
Mayberg, H. (2004). Modulation of cortical-limbic pathways in major
depression: Treatment-specific effects of cognitive behavior therapy.
Archives of General Psychiatry, 61, 34-41.
Brody, A. L., Saxena,
S., Stoessel, P., Gillies, L. A., Fairbanks, L. A., Alborzian, S., Phelps,
N.E., Huang, S., Wu, H., Ho, M. L., Ho, M. K., Au, S. C., Maidment,
K., & Baxter, L. R. (2001)., Regional brain metabolic changes in patients
with major depression treated with either paroxetine or interpersonal
therapy: Preliminary findings. Archives of General Psychiatry,
159, 728-737.
Mayberg,
H. S., Silva, J. A., Brannan, S. K., Tekell, J. L., Mahurin, R. K., McGinnis,
S., & Jarabek, P. A. (2002). The functional neuroanatomy of the placebo
effect. American Journal of Psychiatry, 159, 728-737.
Keller,
M.B. et al. (2000). A comparison of nefazodone, the cognitive behavioral-analysis
system of psychotherapy, and their combination for the treatment of chronic
depression. The New England Journal of Medicine, 342(20), 1462-1470.
Arnow, B. A.
& Constantino, M. J. (2003). Effectiveness of psychotherapy and
combination treatment for chronic depression. Journal of Clinical Psychology,
59, 893-905.
George,
M. (2003). Stimulating the brain. Scientific American, 289,
66-73.
Klein,
E., Kreinin, I., Chistyakov, A., Koren, D., Mecz, L., Marmur, S., Ben-Shachar,
D., & Feinsod, M. (1999). Therapeutic efficacy of right prefrontal slow
repetitive transcranial magnetic stimulation in major depression: A double-blind
controlled study. Archives of General Psychiatry, 56, 315-320.
George,
M. S., Lisanby, S. H., & Sackeim, H. A. (1999). Transcranial magnetic
stimulation: Applications in neuropsychiatry. Archives of General
Psychiatry, 56, 300-311.
December
14, Class 13: Biological perspectives on psychopathology:
Synthesis and Review
Biology
of Psychopathology seminar syllabus, Fall 2003
|
|
Dates:
September 21, Class 1:
Biological perspectives on the psychopathology:
Introduction and overview
September 28, Class 2:Key
biological systems in emotion: Functional neuroanatomy and LHPA
axis
October 5, Class 3: Emotion
regulation and dysregulation
October 12, Class 4: Basic
and clinical neuroscience of fear and anxiety
October 19, Class 5: Functional
neuroanatomy of depression
October 26, Class 6:
LHPA axis in depression and PTSD
November 2, Class 7: Biological
perspectives on addiction and substance-related disorders (Anne
Kelley: guest lecturer)
November 9, Class 8: Biological
perspectives on food intake and eating disorders (Anne Kelley: guest lecturer)
November 16, Class 9:
Biological perspectives on psychopathy (Joe Newman: guest lecturer)
November 23, Class 10: Biological
perspectives on schizophrenia (Giulio Tononi: guest Lecturer)
November 30, Class 11: Biological
perspectives on developmental psychopathology
December 7, Class 12: Biology
and the treatment of psychopathology
December 14, Class 13: Biological
perspectives on psychopathology: Synthesis and Review
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